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Fig. 7 | Biomarker Research

Fig. 7

From: Elevated ZNF704 expression is associated with poor prognosis of uveal melanoma and promotes cancer cell growth by regulating AKT/mTOR signaling

Fig. 7

ZNF704 down-regulation of SORBS3 promotes UM cell growth and migration. A Overlap genes which were up-regulated in ZNF704 knockdown cells and were negatively correlated with ZNF704 in UM patients. B SORBS3 was negatively correlated with ZNF704 in human UM samples based on TCGA database. r = 0.546. p < 0.01. C Time-dependent ROC analysis for prediction of OS in the TCGA cohort. D IHC staining of SORBS3 in tumor (left) and adjacent normal (right) tissues. E Verification of the direct regulatory relationship between ZNF704 and SORBS3 using ChiP-PCR. F Cell migration was detected by transwell. G Cell proliferation was detected by CCK8 in cells as shown in C. ** or ##p < 0.01. *** or ###p < 0.001. (H and I) qRT-PCR analysis of SORBS3 in siCtrl, siZNF704-1 and siZNF704-1 + siSORBS3 OCM1A cells. J Western blot assay of ZNF704 and SORBS3 in siCtrl, siZNF704 and siZNF704 + siSORBS3 in C918 and OCM1A cells. **p < 0.01, ***p < 0.001

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Biomarker Research

ISSN: 2050-7771

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