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Fig. 2 | Biomarker Research

Fig. 2

From: Elevated ZNF704 expression is associated with poor prognosis of uveal melanoma and promotes cancer cell growth by regulating AKT/mTOR signaling

Fig. 2

Up-regulation of ZNF704 is correlated with UM progression. A Overall survival of UM patients who were divided into ZNF704 high (n = 40) and low expression (n = 40) group. B Time-dependent ROC analysis for prediction of OS in the TCGA cohort. C Correlations between ZNF704 expression and chromosome 3q copy number, the density curve on the x and y-axes represents the distribution trend of themselves. The blue line indicates the best fitted linear models and the shaded area indicates the 95% confidence interval. D and E Univariate and multivariate Cox analyses of ZNF704 expression and other clinicopathological parameters in the TCGA cohort. F The correlation between ZNF704 and MYC, KIT, RASGRP3, MDM2, MET and SF3B1 was analyzed in UM tissues from TCGA database. Correlation value and statistical significance were shown in the figure. G GSEA showed that ZNF704 high expression was correlated with inactivated apoptosis, and activated EMT and metastasis gene sets in UM samples

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Biomarker Research

ISSN: 2050-7771

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