Table 2 MALAT1 involved in drug efflux pump function
From: Functions and mechanisms of lncRNA MALAT1 in cancer chemotherapy resistance
Cancer type | Expression | Related drugs | Target | Related genes or pathway | References |
|---|---|---|---|---|---|
Glioma | upregulation | temozolomide | / | ZEB1 | [54] |
Glioma | upregulation | temozolomide | / | p53 | [55] |
Lung cancer | upregulation | cisplatin | / | STAT3/MRP1 and MDR1 | [56] |
Ovarian cancer | upregulation | cisplatin | / | Notch1 | [57] |
Leukemia | upregulation | multidrug resistance | miR-335-3p | ABCA3 | [58] |
Colorectal cancer | upregulation | 5-fluorouracil | miR-20b-5p | ABC, BCRP, MDR1, and MRP1 | [59] |
Oral squamous carcinoma | upregulation | cisplatin | / | PI3K/AKT/m-TOR | [60] |