Table 4 Gal-3 inhibitors in tumor progression
From: Galectins and galectin-mediated autophagy regulation: new insights into targeted cancer therapy
Inhibitor | Target | Effect | Refs |
|---|---|---|---|
Belapectin(GR-MD-02) | Sarcoma, breast and prostate cancer xenografts, musculoskeletal tumors, clinical trials in patients with metastatic melanoma and head and neck squamous cell carcinoma | Inhibition of tumor growth, restore the T cells surveillance | [92] |
GCS-100 | Multiple myeloma, diffuse large B-cell lymphoma cell lines, prostate cancer cell lines | Induction of apoptosis, inhibits cell proliferation and migration | [93] |
TD139 | Thyroid cancer cells | Induction of apoptosis, inhibits migration, invasion and resistance | [94] |
GB1107 | Thyroid cancer cells, gastric cancer, lung adenocarcinoma xenografts, prostate cancer | Inhibits tumor growth and metastasis, inhibits cell migration and invasion | [94] |
Modified citrus pectin (MCP) | Urinary bladder cancer, prostatic cancer, colon cancer xenografts, ovarian cancer cells, breast cancer, renal cell carcinoma | Induction of apoptosis, inhibits proliferation, growth, invasion, migration, adhesion, and metastasis, enhances radiosensitivity | |
HH1-1 | Pancreatic cancer | Suppress cell proliferation, arrest the cell cycle in S phase, induce cell apoptosis, inhibit angiogenesis and impede tumor cell migration and invasion | [96] |
Curcumin | Glioblastoma cells | Reduces induction of UV-C radiation and alkylating agents | [97] |
RN1 | Pancreatic ductal adenocarcinoma | Inhibits cell growth | [95] |