From: Galectins and galectin-mediated autophagy regulation: new insights into targeted cancer therapy
Inhibitor | Target | Effect | Refs |
---|---|---|---|
Thiodigalactoside (TDG) | Melanoma, colon and breast cancer xenografts | Inhibition of angiogenesis and tumor growth, reduction of lung metastases, induction of apoptosis | [88] |
OTX008 | Ovarian cancer xenografts, head and neck squamous cell carcinomas, oral squamous cell carcinoma, thyroid cancer | Inhibition of tumor growth, angiogenesis, proliferation, invasion and migration | [89] |
Anginex (β-pep25) | Ovarian and breast cancer xenografts | Inhibition of tumor growth, proliferation and angiogenesis | [90] |
6DBF7; DB16; DB21 | Lung and ovarian cancer and melanoma xenografts | Inhibition of tumor growth and angiogenesis | [86] |
GM-CT-01 (DAVANAT) | Colon cancer | Inhibition of tumor growth | [91] |