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Table 3 Gal-1 inhibitors in tumor progression

From: Galectins and galectin-mediated autophagy regulation: new insights into targeted cancer therapy

Inhibitor

Target

Effect

Refs

Thiodigalactoside (TDG)

Melanoma, colon and breast cancer xenografts

Inhibition of angiogenesis and tumor growth, reduction of lung metastases, induction of apoptosis

[88]

OTX008

Ovarian cancer xenografts, head and neck squamous cell carcinomas, oral squamous cell carcinoma, thyroid cancer

Inhibition of tumor growth, angiogenesis, proliferation, invasion and migration

[89]

Anginex (β-pep25)

Ovarian and breast cancer xenografts

Inhibition of tumor growth, proliferation and angiogenesis

[90]

6DBF7; DB16; DB21

Lung and ovarian cancer and melanoma xenografts

Inhibition of tumor growth and angiogenesis

[86]

GM-CT-01 (DAVANAT)

Colon cancer

Inhibition of tumor growth

[91]