Skip to main content

Table 1 Baseline characteristics and overall survival for the overall population, GEP BEP, and mIHC BEP

From: Co-enrichment of CD8-positive T cells and macrophages is associated with clinical benefit of tislelizumab in solid tumors

Characteristic

Overalla

(N = 864)

GEP BEP

(n = 629)

mIHC BEP

(n = 67)

Median (range) age, years

60 (18–82)

60 (19–81)

59 (26–78)

Sex, n (%)

 Male

537 (62.2)

396 (63.0)

45 (67.2)

 Female

327 (37.8)

233 (37.0)

22 (32.8)

ECOG performance status, n (%)

   

 0

302 (35.0)

228 (36.2)

20 (29.9)

 1

562 (65.0)

401 (63.8)

47 (70.1)

Cancer type, n (%)

 NSCLC

105 (12.2)

57 (9.1)

25 (37.3)

 GC

78 (9.0)

58 (9.2)

13 (19.4)

 EC

79 (9.1)

66 (10.5)

4 (6.0)

 UC

152 (17.6)

127 (20.2)

25 (37.3)

 HCC

68 (7.9)

50 (7.9)

0 (0.0)

 Other

382 (44.2)

271 (43.1)

0 (0.0)

Patients with any prior anticancer drug therapy, n (%)

   

 0–1

407 (47.1)

297 (47.2)

29 (43.3)

 2

204 (23.6)

147 (23.4)

20 (29.9)

 ≥ 3

190 (22.0)

137 (21.8)

18 (26.9)

 Unknown

63 (7.3)

48 (7.6)

0 (0.0)

Median overall survival, months (95% CI)

11.1 (9.5–11.7)

11.1 (9.6–11.9)

11.2 (6.2–16.1)

  1. BEP biomarker-evaluable population, CI confidence interval, EC esophageal cancer, ECOG Eastern Cooperative Oncology Group, GC gastric cancer, GEP gene expression profiling, HCC hepatocellular carcinoma, mIHC multiplex immunohistochemistry, NSCLC non-small cell lung cancer, UC urothelial cancer
  2. aAll patients enrolled in A317-001 (NCT02407990), A317-102 (NCT04068519), and A317-204 (NCT04004221)