Fig. 3
Distinct TME in four signature-defined subgroups in the GEP BEP. A Heatmap of 29 key TME-described gene signatures. B Box plot showing signature score differences in cytotoxic T-cell, T-cell traffic, MHC I, and tumor proliferation signatures among four subgroups defined by CD8+ T-cell and Mφ signatures. C Heatmap showing the differentially expressed genes among four subgroups defined by CD8+ T-cell and Mφ signatures. D GSEA of pro-inflammatory Mφ polarization signal between CD8Hi/MφHi and CD8Lo/MφHi subgroups. E: Heatmap showing the differentially expressed genes associated with pro-inflammatory Mφ polarization among four subgroups defined by CD8+ T-cell and Mφ signatures. *P < .05, **P < .01, ***P < .001, ****P < .0001. BEP, biomarker-evaluable population; FDR, false discovery rate; GSEA, gene set enrichment analysis; Mφ, macrophages; MHC I, major histocompatibility complex class I; OS, overall survival; TME, tumor microenvironment