Neutrophil extracellular traps primed intercellular communication in cancer progression as a promising therapeutic target

Table 2 NETs as a valuable marker in Cancer from the clinical perspective

Year	Method	Samples number	Chosen markers of NETs	Type of Cancer	Function	Reference
2016	ELISA	35	MPO-DNA complex	Colorectal cancer	correlated with the reduction in DFS	[42]
2018	ELISA	161	Citrullinated histone H3	Pan-cancer	prognostic blood marker	[109]
2019	ELISA	45	NE-DNA complex	Breast cancer	associated with clinical stages	[117]
2019	ELISA	27	MPO-DNA complex	Colorectal cancer	correlated with shorter survival	[41]
2019	ELISA	104	MPO-DNA complex	Pancreatic ductal adenocarcinoma	related to the clinical stage	[19]
2019	ELISA	957	Citrullinated histone H3	Pan-cancer	associated with higher mortality	[110]
2019	IHC	317	Citrullinated histone H3	Pancreatic ductal adenocarcinoma	prognostic factor	[113]
2019	ELISA	138	circulating DNA	Pan-cancer	related to cancer-related stroke	[114]
2019	ELISA	75	MPO-DNA complex	Esophagogastric and lung adenocarcinoma	correlated with advanced stage	[106]
2020	ELISA	356	NE-DNA complex	Gastric Adenocarcinoma	diagnostic, therapeutic predictive, and prognostic value	[108]
2020	ELISA	461	MPO-DNA complex	Breast cancer	metastases predictor	[11]
2022	IHC	321	MPO	Pan-cancer	prognostic factor	[13]
2022	ELISA	25	MPO-DNA complex	Breast cancer	monitoring HER2 antibody–drug-associated vasculitis activity	[116]

ISSN: 2050-7771