Table 1 Comparison of patients’characteristics in the grade 1 to 2 and 3a follicular lymphoma
Characteristics | Grade1-2 | Grade3a | P value |
|---|---|---|---|
No. of patients | 1403 | 765 | 543 |
Age | |||
Median, years (range) | 52 (20–95) | 54 (18–91) | |
> 60 years | 365 (26.0) | 245 (32.0) | 0.003 |
Male | 696 (49.6) | 346 (45.2) | 0.06 |
ECOG | |||
2–4 | 211 (16.9) | 100 (14.5) | 0.19 |
Missing data | 156 (11.1) | 78 (10.1) | |
Rai stage | |||
III-IV | 1103 (83.2) | 519 (70.7) | < 0.001 |
Missing data | 78 (5.5) | 31 (4.0) | |
B symptoms | |||
Yes | 176 (19.6) | 106 (21.7) | 0.37 |
Missing data | 504 (35.9) | 278 (36.3) | |
Lymph nodes > 4 | |||
Yes | 838 (65.0) | 399 (59.5) | < 0.001 |
Missing data | 114 (8.1) | 65 (8.5) | |
Extranodal disease | |||
Yes | 615 (55.1) | 292 (50.4) | 0.07 |
Missing data | 287 (20.4) | 186 (24.3) | |
Disease bulk > 6 cm | |||
Yes | 275 (23.2) | 146 (22.5) | 0.77 |
Missing data | 219 (15.6) | 117 (15.2) | |
Marrow involved | |||
Yes | 457 (34.1) | 128 (18.1) | < 0.001 |
Missing data | 62 (4.4) | 60 (7.8) | |
Spleen involved | |||
Yes | 362 (29.2) | 208 (31.7) | 0.29 |
Missing data | 167 (11.9) | 109 (14.2) | |
Ki-67 > 30% | |||
Yes | 596 (47.7) | 610 (89.3) | < 0.001 |
Missing data | 154 (10.9) | 82 (10.7) | |
HGB < 120 g/L | |||
Yes | 341 (25.2) | 170 (23.0) | 0.27 |
Missing data | 55 (3.9) | 27 (3.5) | |
LMR > 10 | |||
Yes | 193 (16.4) | 67 (10.0) | 0.0001 |
Missing data | 96 (12.5) | 10 (5.5) | |
LDH > 245U/L | |||
Yes | 292 (22.1) | 243 (31.7) | |
Missing data | 81 (5.8) | 40 (5.2) | < 0.0001 |
β2-MG ≥ 2.7 mg/L | |||
Yes | 586 (44.6) | 316 (43.1) | 0.51 |
Missing data | 92 (6.5) | 32 (4.1) | |
R-CHOP regimen | |||
Yes | 862 (61.4) | 543 (70.9) | < 0.0001 |
Missing data | 164 (11.6) | 77 (10.1) | |
POD24 | |||
Yes | 287 (20.4) | 151 (19.7) | 0.70 |
Missing data | 18 (1.2) | 7 (0.9) | |