Fig. 4
From: Retinal determination gene networks: from biological functions to therapeutic strategies
The interaction of RDGN with key signaling in cancer. TGFβ and Wnt signaling pathways are vital for tumorigenesis and progression. RDGN is involved in the regulation of TGF-β and Wnt signaling pathways. DACH1 inhibits smad complex, while SIX/EYA activates TGF-ßR. DACH1 represses ß -catenin, while SIX/EYA activates Wnt signaling. EYA could switch DACH1 repressional function and enhance activation of SIX. Silencing the expression of SIX or interfering with the SIX/EYA complex using small molecule compounds can block the function of SIX. Moreover, EYA phosphatase activity can be inhibited by biochemical inhibitors. The use of demethylating agents can reactivate DACH1 expression. Therefore, targeting RDGN members holds promise as a cancer treatment strategy