Fig. 3
From: Retinal determination gene networks: from biological functions to therapeutic strategies
The Role of RDGN in the Cell Cycle. DACH1 inhibits cyclin D1 transcription, resulting in G1-phase arrest. SIX1/EYA facilitates G1 progression via promoting the transcription of cyclin D1. Moreover, DACH1 also inhibits cyclin A, but SIX1 enhances cyclin A in S-phase. DACH1 increases the protein abundance of p21 and p27, further suppressing cdk2/cyclin E activity and finally preventing cells from entering S-phase. DACH1 also binds with p53 and synergizes p21 induction, and inhibits Cdc25, reducing the activity of Cdc2 to arrest cells in G2/M. (The role of RDGN in the cell cycle was adapted from Fig. 2 in [76].)