Fig. 7

Common changes of hepatic transcripts due to differential diet intake, ages, and FXR KO in association with the expression of genes implicated in human HCC patient survival. A Venn diagram shows the numbers of common genes (transcripts) (fold change ≥2 and adjusted p value < 0.05). B A heatmap reveals transcript levels of mouse genes implicated in hepatic metabolic disease (n = 76) and human genes differentially expressed in human HCC and healthy livers. C Pathway enrichment analyses of 76 mouse hepatic genes that are implicated in human HCC survival using Metascape (adjusted p value < 0.05). The numbers of differentially expressed genes in each pathway are shown in the bar graph. LIHC, liver hepatocellular carcinoma