Fig. 6From: The essential roles of FXR in diet and age influenced metabolic changes and liver disease development: a multi-omics studyThe effects of FXR KO on hepatic metabolomes. A Principal component analyses of hepatic metabolomes of WT and FXR KO mice fed with differential diets until 5, 10, and 15 months old. B Venn diagrams show the numbers of distinct and overlapping metabolites that were altered by FXR KO in CD- and WD-fed mice (raw p value < 0.05 and FDR < 0.1). C Quantitative enrichment analyses of FXR KO altered metabolites. The top 10 pathways are shown (p value < 0.05). Common pathways in both CD- and WD-fed mice are marked in purpleBack to article page