Fig. 5

The effects of FXR KO on hepatic transcriptomes. A Principal component analyses of liver transcriptomes of WT and FXR KO mice fed with differential diets until 5, 10, and 15 months old. B Venn diagrams show the numbers of genes differentially expressed due to FXR KO (fold change ≥2 and adjusted p value < 0.05). C Pathways and numbers of genes that were up or down regulated by FXR KO found in both CD- and WD-fed mice based on Metascape. The top 20 pathways are shown (adjusted p value < 0.05). Common and specific transcriptomic changes (pathways and numbers of differentially expressed genes in each pathway) due to FXR KO in CD- and WD-fed mice