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Fig. 3 | Biomarker Research

Fig. 3

From: The essential roles of FXR in diet and age influenced metabolic changes and liver disease development: a multi-omics study

Fig. 3

The effects of ages on hepatic transcriptomes in WT and FXR KO mice on different diets. A Principal component analyses of liver transcriptomes in WT and FXR KO mice fed with either a CD or WD. B Venn diagrams show the numbers of genes differentially expressed due to age (15 vs. 5) in WT or FXR KO mice (fold change ≥2 and adjusted p value < 0.05). C Pathway enrichment analyses for up and downregulated genes affected by age based on Metascape. The top 20 pathways are shown (adjusted p value < 0.05). Age-regulated pathways shared by WT and FXR KO mice are in purple. The numbers of differentially expressed genes in each pathway are shown in the bars

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