Fig. 1

Schematic representation of human Mafs structures. The seven members of Mafs are shown with their sizes and domain arrangement [20, 25, 26]. Large Mafs contain a transactivation domain, an extended homology region, a basic domain, and a leucine zipper, while small Mafs lack a transactivation domain. The posttranslational modifications of Mafs in human cancer are indicated on the first line of amino acid codes below the bar, while the second row indicates highly conserved PTM sites in mouse. The red amino acid represents phosphorylation sites, the green indicates sumoylation sites and the yellow implies ubiquitylation sites