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Fig. 1 | Biomarker Research

Fig. 1

From: The landscape overview of CD47-based immunotherapy for hematological malignancies

Fig. 1

Overall structures of CD47, SIRPα and CD47 complex. A Structure of the ectodomain of human CD47 (PDB#2VSC). B Interaction of CD47 with three major ligands (SIRPα, TSP-1 and integrin). The figure was created by Biorender.com. C Complete extracellular region of human SIRPα (PDB#2WNG). The structures were reconstructed using VMD software. Abbreviations: CD47, cluster of differentiation 47; IgSF, immunoglobulin superfamily; ITIM, immunoreceptor tyrosine-based inhibitory motif; SHPS-1/2, protein tyrosine phosphatase substrate-1/2; SIRPα, signal-regulatory protein α; TSP-1: thrombospondin-1

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