Fig. 1
From: The function and clinical implication of YTHDF1 in the human system development and cancer
The composition and function of m6A modification. The m6A modification is installed by writers, including METTL3, METTL14, METTL16, CBLL1, WTAP, RBM15B, ZC3H3, VIRMA and KIAA1429. FTO and ALKBH5 are m6A erasers that remove m6A modifications. The m6A-modified RNA reader proteins (YTHDF1/2/3, YTHDC1/2, IGF2BP1/2/3, and HNRNPC/A2B1) are required to recognize m6A and regulate the RNA metabolism