Table 3 Clinical trials of mRNA vaccine against multi-tumor
From: Advances of mRNA vaccine in tumor: a maze of opportunities and challenges
NCT number | Status | Diseases | Phase | Encoding mRNA | Adjuvants | Delivery tools | Additional therapies |
|---|---|---|---|---|---|---|---|
NCT00529984 | Completed | Colorectal Cancer; Breast Cancer; Lung Cancer; Pancreatic Cancer; Colon Cancer | I/II | TAA: CEA | Â | VRP | - |
NCT03948763 | Active, not recruiting | Neoplasms; NSCLC; Pancreatic Neoplasms Colorectal Neoplasms | I | TSA: KRAS mutation (G12C, G12D, G12V, G13C) | - | LNP | pembrolizumab |
NCT03289962 | Active, not recruiting | Melanoma; NSCLC; Bladder Cancer; Colorectal Cancer; Tripple negative breast cancer; Renal Cancer; Head and Neck Cancer; Other Solid Cancers | I | TSA: poly-neoepitope | - | Lipoplex | Atezolizumab |
NCT03323398 | Terminated | Relapsed/Refractory Solid Tumor Malignancies or Lymphoma; Ovarian Cancer | I | OX40L, IL-23, IL-36γ | - | LNP | Durvalumab |
NCT03639714 | Active, not recruiting | NSCLC; Colorectal Cancer; Gastroesophageal Adenocarcinoma; Urothelial Carcinoma | I/II | TSA: poly-neoepitope | Â | Â | Nivolumab; ipilimumab |
NCT00004604 | Completed | Breast Cancer; Colorectal Cancer; Extrahepatic Bile Duct Cancer; Gallbladder Cancer; Gastric Cancer Head and Neck Cancer; Liver Cancer; Lung Cancer; Metastatic Cancer; Ovarian Cancer; Pancreatic Cancer; Testicular Germ Cell Tumor | I | TAA: CEA | - | DCs-based | - |
NCT03468244 | Unknown | Advanced Esophageal Squamous Carcinoma; Gastric Adenocarcinoma; Pancreatic Adenocarcinoma; Colorectal Adenocarcinoma | - | TSA: poly-neoepitope | - | Lipo-polyplex | - |