Table 3 Top 50 proteins with increased expression in NPC1 CSF

CCL18

C–C Motif Chemokine Ligand 18

4.88E-04

7.36

NEFL

Neurofilament light

3.36E-03

6.50

CHIT1

Chitotriosidase-1

3.36E-03

6.19

MIF

Macrophage Migration Inhibitory Factor

9.05E-03

3.68

CHI3L1

Chitinase-3-like protein 1, YKL-40

1.12E-02

3.53

SNCG

Gamma-synuclein

1.85E-02

3.53

TMSB10

Thymosin β-10

2.03E-02

3.51

CALB2

Calretinin

5.77E-04

3.41

CPVL

Carboxypeptidase Vitellogenic Like

2.56E-02

3.41

MAPT

Microtuble Associated Protein Tau

2.32E-02

3.39

ENO1

Enolase 1

3.36E-03

3.36

PARK7

Parkinson Associated Deglycanase, DJ-1

4.87E-03

2.97

PDCD5

Programmed Cell Death Protein 5

1.19E-02

2.95

DNAJA2

DnaJ Heat Shock Protein Family (Hsp40) member A2

1.69E-02

2.85

FABP5

Fatty Acid Binding Protein 5

3.44E-02

2.77

CD14

Cluster of Differentiation 14

7.74E-02

2.75

NSFL1C

NSFL1 cofactor p47

2.03E-02

2.73

RBKS

Ribokinase

8.95E-03

2.68

ATOX1

Antioxidant 1 Copper Chaperone

1.62E-02

2.64

GLO1

Lactoylglutathione lyase

2.09E-02

2.55

LILRB2

Leukocyte Immunoglobulin Like Receptor A2

1.94E-02

2.51

NOS1

Nitric oxide synthase 1 (neuronal)

7.76E-03

2.48

WARS

Tryptophanyl-tRNA synthetase, cytoplasmic

1.73E-03

2.45

GDF15

Growth Differentiation Factor 15

3.81E-02

2.36

CCL24

C–C Motif Chemokine Ligand 24

1.87E-02

2.27

INPP1

Inositol Polyphophate 1-phosphatase

4.87E-03

2.25

ITGB2

Integrin beta chain-2

3.05E-02

2.25

ATP5IF1

ATP Synthase Inhibitory factor Subunit 1

1.69E-02

2.23

LILRA2

Leukocyte immunoglobulin-like receptor subfamily A member 2

2.42E-02

2.23

SCRN1

Secernin-1

3.44E-02

2.19

IL1R2

Interleukin 1 Receptor Type 2

3.36E-03

2.11

DDC

DOPA Decarboxylase

8.29E-03

2.11

GLOD4

Glyoxalase domain-containing protein 4

9.22E-03

2.11

PEBP1

Pohosphatidylethanolamine-binding protein

1.87E-02

2.11

MSR1

Macrophage scavenger receptor 1

2.62E-02

2.10

CPPED1

Calcineurin-like phosphoesterase domain-containing protein 1

6.36E-02

2.10

PPP3R1

Calcineurin subunit B type 1

1.12E-02

2.04

CCL8

Chemokine (C–C motif) ligand 8

1.45E-02

2.04

KLK4

Kallikrein-related peptidase 4

4.88E-02

2.04

PTS

6-pyruvoyl-tetrahydropterin synthase

3.36E-03

2.03

PHOSPHO1

Phosphoethanolamine/phosphocholine phosphatase 1

1.04E-02

2.03

TXNRD1

Thioredoxin Reductase 1

4.42E-02

2.03

CD300LF

CMRF35-like molecule 1

2.56E-02

2.00

ENO2

Neuron specific enolase

9.22E-03

1.97

OLR1

Oxidized low density lipoprotein receptor 1

5.60E-02

1.96

LGALS8

Gelectin 8

1.62E-02

1.96

SCGN

Secretagogin

4.05E-03

1.96

CCL3

Macrophage Inflammatory Protein 1-alpha

1.11E-02

1.96

LGMN

Legumain

2.03E-02

1.94