Fig. 4
From: Identification of cerebral spinal fluid protein biomarkers in Niemann-Pick disease, type C1
Correlation of NPC1 cerebrospinal fluid CALB2/Calretinin levels with NPC1 clinical phenotype. a Decreased CSF CALB2 levels were associated with later age of neurological disease onset in individuals with NPC1 (p =  = 0.0210, rho = -0.41). b The negative correlation between CSF CALB2 levels and age of neurological onset (p = 0.0076, rho = -0.48) was also present when excluding a 40 yo individual. CSF CALB2 levels did not correlate with the concurrent NPC Neurological Severity Score (c). CALB2 levels showed a modest correlation with the Annual Severity Increment Scores (d)