Fig. 3
From: Identification of cerebral spinal fluid protein biomarkers in Niemann-Pick disease, type C1
Clinical phenotype correlations with Proximal Extension Assay NPX values. a CSF CCL18 NPX values showed a negative correlation (p = 0.0101, rho = -0.75) with age of neurological onset. Open circles represent individuals not on miglustat and filled circles represent individuals on miglustat. NPX correlations were performed on the combined cohorts. b CSF CHI3L1 NPX values were positively correlated ( p = 0.0002, rho = 0.83) with the total NPC Neurological Severity Score. Both CSF 6-pyruvoyl-tetrahydropterin-synthase (PTS) (c) and CALB2 (d) NPX values were positively correlated (p = 0.0052, rho = 0.79 and p = 0.0418, rho = 0.74, respectively) with Annual Severity Increment Scores. Y-axis NPX values are log2