Fig. 2
From: Identification of cerebral spinal fluid protein biomarkers in Niemann-Pick disease, type C1
Validation of differentially expressed proteins. ELISA assays for PARK7 (a), CALB2/calretinin (b), CHI3L1/YKL-40 (c), MIF (d) and CCL18 (e) confirmed increased levels of these five proteins in cerebrospinal fluid from individuals with NPC1 relative to age-appropriate comparison samples. Laboratory testing also validated increased levels of neuron specific enolase (ENO2) in cerebrospinal fluid from individuals with NPC1 (f). Samples obtained from individuals with NPC1 on miglustat are indicated by an open circle. P-values are from unpaired, two-sided t-tests