Fig. 2
Classification of cancers based on regulatory patterns of cuproptosis genes. A Diagram showing the cuproptosis regulating patterns in different cancers and the classification of cancers with distinct cuproptosis subtypes. B The waterfall plot depicting the overall mutation status of top30 mutated genes in different STAD subgroups. The upper box indicates the TMB of each sample, the right columns show the mutated types of each gene, the numbers between the waterfall plot and right columns show the mutated frequency of each gene, and the stacked bars below show the fraction of conversions in each sample. C Sankey diagram depicting the sample distributions between cuproptosis groups and traditional TCGA STAD classifications. D Boxplot showing the intergroup differences in DNA repairing scores in STAD patients. Median lines in each box represented the median value, different asterisks indicated the results of p-value (*P < 0.05; **P < 0.01). E Boxplot showing the intergroup differences in the infiltrations of TME-related cells in STAD patients. Median lines in each box represented the median value, different asterisks indicated the results of p-value (*P < 0.05; **P < 0.01; ***P < 0.001). F Boxplot showing the intergroup differences in the infiltrations of TME-related cells in COAD patients. Median lines in each box represented the median value, different asterisks indicated the results of p-value (*P < 0.05; **P < 0.01; ***P < 0.001). G The expression profile of immune checkpoint genes in different COAD subgroups. Median lines in each box represented the median value, different asterisks indicated the results of p-value (*P < 0.05; ***P < 0.001). H The hill plot exhibits the distributions of IPS values on anti-PD1 and anti-CTLA4 immunotherapy between different subgroups of COAD patients. Dotted lines in each hill show the median IPS value. I Survival curve showing the disease-free survival (DFS) difference among different cuproptosis groups in COAD. J Survival curve showing the progression-free survival (PFS) difference among different cuproptosis groups in COAD. K The histogram showing the COAD sample distributions in different tumor stages. L Boxplot showing the intergroup differences in the infiltrations of immune cells in OV patients. Median lines in each box represented the median value, different asterisks indicated the results of p-value (*P < 0.05; **P < 0.01; ***P < 0.001). M Boxplot showing the intergroup differences in the infiltrations of stromal cells in OV patients. Median lines in each box represented the median value, the asterisks indicated the results of p-value (**P < 0.01). N The expression profile of immune checkpoint genes in different OV subgroups. Median lines in each box represented the median value, different asterisks indicated the results of p-value (**P < 0.01; ***P < 0.001). O The hill plot exhibits the distributions of IPS value on anti-PD1 and anti-CTLA4 immunotherapy between different subgroups of OV patients. Dotted lines in each hill show the median IPS value