Fig. 1

Multi-omics features of cuproptosis markers in pan-cancer. A. Somatic mutation status of cuproptosis markers in 20 cancer types visualized via waterfall plot. Top bar plot showing the mutated gene counts of cuproptosis markers in each sample, the numbers between waterfall plot and mutated types showing the mutated frequency of each cuproptosis markers. B. Pie plot showing the copy number variations of cuproptosis markers in 21 cancers. C. Expressional difference of cuproptosis markers among 10 cancer types visualized via heatmap, 100 samples were randomly selected for each cancer. D. Differential expression of cuproptosis markers in different cancers compared with adjacent normal tissues showed by dot plot. E. Dot plot showing the prognostic value of cuproptosis markers in different cancers. F-J. Petal graph showing the multi-features correlation degrees of cuproptosis markers in 10 cancers, covering immune score, stromal score, MSI and TMB. The cancer types are shown in the upper left or upper right corner, respectively. The length of the petals indicated the correlation degrees, opaque petals indicated positive correlations and translucent petals indicated negative correlations. K. NMF clustering results via cuproptosis markers for dimensionality reduction in BLCA patients. L. Validation of the clustering result of BLCA patients showed by two-dimensional t-SNE plot. M. Boxplot showing the intergroup comparing results of immune scores in 10 cancers. Median-lines in each box represented median value, different asterisks indicated the results of p-value (*P < 0.05; **P < 0.01; ***P < 0.001) N. Boxplot showing the intergroup comparing results of stromal scores in 10 cancers. Median-lines in each box represented median value, different asterisks indicated the results of p-value (*P < 0.05; **P < 0.01; ***P < 0.001). O Boxplot showing the intergroup comparing results of TMB in 10 cancers. Median-lines in each box represented median value, different asterisks indicated the results of p-value (*P < 0.05; **P < 0.01; ***P < 0.001). P Boxplot showing the intergroup comparing results of MSI in 10 cancers. Median-lines in each box represented median value, different asterisks indicated the results of p-value (*P < 0.05; **P < 0.01; ***P < 0.001). Q-V. Survival curves revealed the prognostic difference between different subgroups in COAD (Q), HNSC (R), KIRC (S), LIHC (T), LUAD (U), and UCEC (V) separately