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Fig. 3 | Biomarker Research

Fig. 3

From: MiR-124-3p impedes the metastasis of non-small cell lung cancer via extracellular exosome transport and intracellular PI3K/AKT signaling

Fig. 3

miR-124-3p is down-regulated by LINC00511. a The relative RNA expression of different LncRNA in A549 cells. b The expression of LINC00511 in NSCLC by analyzing the TCGA dataset using the GEPIA database. LUAD means Lung Adenocarcinoma, LUSC means Lung Squamous Carcinoma. Red box means tumor, gray box means normal tissue. c Luciferase activity from NSCLC cells transfected with LINC00511 and luciferase reporter constructs containing WT-miR-124-3p or MUT-miR-124-3p binding sequences for LINC00511. d The relative expression of miR-124-3p in A549 and NCI-H1299 cells with LINC00511 knockdown. e Exosome concentration in medium from A549 and NCI-H1299 cells transfected with siRNA against LINC00511. f Growth curves generated with OD450 data with the CCK8 assay for A549 cells with LINC00511 knockdown. g Growth curves generated with OD450 data with the CCK8 assay for NCI-H1299 cells with LINC00511 knockdown. h Transwell assays performed with A549 cells transfected with si-LINC00511 or si-LINC00511 + miR-124-3p inhibitor. i Transwell assays performed with NCI-H1299 cells transfected with si-LINC00511 or si-LINC00511 + miR-124-3p inhibitor. Data are shown as the mean ± SD. *P < 0.01, **P < 0.001, ***P < 0.0001, and ****P < 0.00001

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