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Fig. 2 | Biomarker Research

Fig. 2

From: MiR-124-3p impedes the metastasis of non-small cell lung cancer via extracellular exosome transport and intracellular PI3K/AKT signaling

Fig. 2

miR-124-3p inhibits exosome secretion, uptake and migratory abilities of NSCLC cells. a Concentration of exosomes in medium from A549 cells transfected with miR-124-3p mimic or inhibitor. b Images of the uptake of exosomes fluorescently labeled with PKH67 (green) by A549 after incubation for 24 hours. Images were acquired under confocal microscopy. c Growth curves generated with OD450 data with the CCK8 assay for A549 cells transfected with miR-124-3p mimic or inhibitor. d Images of colony forming assays for A549 cells transfected with miR-124-3p mimic or inhibitor. Cells were fixed and stained with crystal violet. e Images of wound healing of A549 cells transfected with miR-124-3p mimic or inhibitor. f Transwell assays performed with A549 cells transfected with miR-124-3p mimic or inhibitor. Cells were fixed and stained with crystal violet. Data are shown as the mean ± SD. *P < 0.01, **P < 0.001, ***P < 0.0001, and ****P < 0.00001

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