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Fig. 1 | Biomarker Research

Fig. 1

From: MiR-124-3p impedes the metastasis of non-small cell lung cancer via extracellular exosome transport and intracellular PI3K/AKT signaling

Fig. 1

The release of exosomes affects tumor invasion and migration. a Size measurement of exosomes from NSCLC patient serum samples by NTA. b Image of exosomes captured with Cryo-TEM. Scale bar, 100 nm. c Images of Western blot analysis to detect the expression of exosomal markers, TSG101 and CD81, in vesicles isolated from NSCLC patient serum samples and NSCLC cells. Full-length blots are presented in Additional file 3. d Exosome concentration in serum of early and late-stage NSCLC patients. e Exosome concentration of NSCLC cell lines and normal lung epithelium cell line in culture. f Growth curve of A549 cells treated with different concentrations of an inhibitor of exosome release, GW4869. g Growth curve of NCI-H1299 cells treated with different concentrations of GW4869. h Images of colony forming assays for A549 and NCI-H1299 cells treated with GW4869. i Images of wound healing assays for A549 treated with GW4869. j Transwell assays performed with A549 treated with GW4869. Data are shown as the mean ± SD. *P < 0.01, **P < 0.001, ***P < 0.0001, and ****P < 0.00001

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