Fig. 6From: Protein biomarkers in cervicovaginal lavages for detection of endometrial cancerCervicovaginal levels of protein biomarkers in patients with EC vary based on histological type, MMR status, tumor size, and myometrial invasion. A volcano plot analysis was used to assess differences in the protein levels among patient with EC stratified based on tumor characteristics, including histological type and grade, mismatch repair (MMR) protein expression, tumor size, and presence of myometrial invasion (A). Statistical significance was determined using multiple t-test with the false discovery rate (FDR) correction. A volcano plots indicate log2 differences (x axis) and -log10(q value) (y axis). Proteins with q < 0.01 were considered significant. A correlation analysis between cervicovaginal levels of 72 proteins with the tumor size (measured in cm) and the depth of myometrial invasion (measured in mm) (B). Correlation coefficients (r) were calculated using the Spearman’s rank correlation and depicted as a heatmap. P values are indicated with black circles. The biomarkers identified to be significant in both volcano and correlation analyses are marked with an asterisk (*)Back to article page