Table 1 Coding variants mapped genes known to associate with both birth defects and cancers
Gene ID | Associated Birth defects | Associated Cancers |
|---|---|---|
AXIN2 | Cleft Lip | Mutations in AXIN2 gene were found in patients with colorectal or hepatocellular carcinoma, prostate cancer, ovarian or lung cancer |
BMP1 | Gastroschisis | Therapeutic biomarker for gastric cancer |
CR1 | Tetralogy of Fallot | Susceptibility to gallbladder cancer and a prognosis predictor in non-small cell lung cancer |
ERBB2 | Neural tube defect | biomarkers in breast invasive ductal carcinoma, lung adenocarcinoma, colon adenocarcinoma, bladder urothelial carcinoma, and invasive breast carcinoma |
RYR1 | Tetralogy of Fallot | Prognostic biomarker of uterine cancer |