Fig. 1

Tobacco smoking associates increased NF1 mutation in gliomas. A Overview of mutant genes in smoking and non-smoking cohorts. B Forest plot of frequency of gene mutation. The frequency of NF1 mutation is significantly higher in smoking group, *: P ˂ 0.05. C The spectrum of NF1 variants is represented with each mutation shown only once per patient. D-E Correlation between gene mutations. NF1 and IDH1 mutations are mutually exclusive, *: P ˂ 0.05. F Survival analysis shows glioma patients with NF1 mutations have worse overall survival. P = 0.0018