Fig. 1
From: Development of a novel BRCAness score that predicts response to PARP inhibitors
Development of the BRCAness score that correlates with DNA repair and HRD, which has the highest AUC for BRCA1 mutation, in breast cancer. A Correlation plots of the AUC level of the BRCAness score with BRCA1 mutation in the METABRIC and TCGA cohorts by Spearman’s rank correlation test. Blue shaded areas represent AUC lower than 0.65 in either TCGA or METABRIC. B Scatter plots of the score level between the BRCAness score and DNA-repair score in the TCGA, METABRIC, and GSE96058 cohorts, and HRD score in the TCGA cohort. Spearman’s rank correlation was used for the analysis. C ROC curve of the BRCAness score, DNA repair score, BRCA1 and BRCA2 gene expression, MKI67 expression, and HRD score, with the AUC in the TCGA and METABRIC cohorts. AUC, area under the curve; HRD, homologous recombinant deficient; ROC, receiver operating characteristic