Fig. 7

The verification of circ_0002078/miR-185-3p/TCF7L1 axis and the function of circ_0002078/miR-185-3p. A The expression of TCF7L1 in patient specimens were significantly increased. B The expression of miR-185-3p in patient specimens were significantly decreased. C The expression of circ_0002078 in patient specimens were significantly increased. D There was a strong linear correlation between TCF7L1 and circ_0002078. E Higher expression of TCF7L1 was associated with shorter TTFT. F Lower expression of miR-185-3p was associated with shorter OS. G Higher expression of circ_0002078 was associated with shorter OS. H The luciferase activity analysis showed that miR-185-3p can bind to the circ_0002078. I The luciferase activity analysis shows that miR-185-3p can bind to 3′UTR of TCF7L1. J Overexpression of miR-185-3p inhibited cell proliferation. K Efficiency verification of circ_0002078 knockdown in EHEB cells by qRT-PCR. L Knockdown of circ_0002078 inhibited cell proliferation. M, N Knockdown of circ_0002078 promoted cell apoptosis. O-Q Knockdown of circ_0002078 led to G2/M cell cycle arrest. All the results are expressed as mean ± SEM. (^*p < 0.05, ^**p < 0.01, ^***p < 0.001)