Skip to main content
Fig. 8 | Biomarker Research

Fig. 8

From: SGOL2 is a novel prognostic marker and fosters disease progression via a MAD2-mediated pathway in hepatocellular carcinoma

Fig. 8

Upregulated MAD2 expression predicted poor prognosis in HCC and hub gene analysis positively related to both SGOL2 and MAD2. A MAD2 mRNA level is higher in HCC tissues than that in normal liver tissues (UALCAN). B MAD2 has a positive relation with SGOL2 in HCC (GEPIA). C Highly expressed MAD2 predicted poor prognosis in HCC. D Forty-seven genes positively correlated with both SGOL2 and MAD2, as shown by Venn diagram analysis. E The interaction network of the 47 genes. F KEGG enrichment of the 47 genes. G The graph shows the interaction network of the top 15 hub genes. H-I GO analysis and KEGG enrichment of the top 15 hub genes. HR: hazard ratio. J The role and mechanism of SGOL2 in HCC cells. SGOL2 forms a SGOL2-MAD2 complex and further regulates MAD2, resulting in dysregulation of the cell cycle and finally enhancing HCC malignant behaviors

Back to article page