Dysfunction and ceRNA network of the tumor suppressor miR-637 in cancer development and prognosis

Shen, Jinze; Liang, Chenhao; Su, Xinming; Wang, Qurui; Ke, Yufei; Fang, Jie; Zhang, Dayong; Duan, Shiwei

doi:10.1186/s40364-022-00419-8

Biomarker Research

Table 2 Roles of miR-637 in vivo and in vitro

From: Dysfunction and ceRNA network of the tumor suppressor miR-637 in cancer development and prognosis

Diseases	Targets	Effects in vitro	Cell lines	Effects in vivo	Laboratory animals	Ref
GBM/LGG	AKT1	growth↓, invasion↓, and migration↓	U251 and U87	tumorigenesis↓	nude mice	[9]
	HMGA1	proliferation↓, invasion↓, and migration↓	U251 and U87	tumor growth↓	nude mice	[42]
	CDK6	proliferation↓ and invasion↓	LN18	—	—	[50]
GBM	WNT7A	proliferation↓	U251 and LN229	tumor growth↓	BALB/c mice (4 weeks)	[10]
PTC	HEMGN	cell cycle↓, proliferation↓, migration↓, and apoptosis↑	TPC-1 and SW579	tumor growth↓	BALB/c mice (5 weeks)	[12]
PTC	AKT1	proliferation↓, invasion↓, and migration↓	TPC-1 and HTH83	tumorigenesis↓	female BALB/C nude mice (8–12 weeks)	[13]
TC	KLK4	migration↓ and apoptosis↑	K1 and TPC-1	tumor growth↓	female BALB/C nude mice (5 weeks)	[52]
NSCLC	—	proliferation↓, invasion↓, and migration↓	H1299 and HCC827	—	—	[14]
GC	CALA	apoptosis↑	AGS	—	—	[55]
	APLN	proliferation↓, invasion↓, and apoptosis↑	SGC-7901	—	—	[15]
	MMP19	invasion↓ and migration↓	BGC823 and MGC803	—	—	[16]
	AKT1	invasion↓ and migration↓	SGC-7901 and AGS	—	—	[17]
HCC	LIF	growth↓ and apoptosis↑	HepG2 and Bel7404	tumor growth↓	female BALB/c nude mice (4–6 weeks)	[21]
	USP21	proliferation↓ and invasion↓	HepG2 and Hep3B	—	—	[51]
	AKT1	proliferation↓ and invasion↓	Huh-7 and Sk-Hep-1	—	—	[20]
	AKT1	proliferation↓ and invasion↓, migration↓	Huh7 and MHCC-97H	—	—	[18]
CRC	NUPR1	invasion↓ and migration↓	HCT116 and HT29	—	—	[22]
CRC	WNT1	invasion↓, migration↓, and apoptosis↑	HCT116 and SW480	—	—	[56]
PDAC	AKT1	growth↓ and apoptosis↑	Capan-2 and BxPC-3	—	—	[23]
CHOL	LY6E	proliferation↓, invasion↓, migration↓, and apoptosis↑	HuCCT1 and RBE	tumor growth↓, metastasis ↓	nude mice	[36]
CHOL	CTSB	proliferation↓ and migration↓	QBC939	—	—	[24]
OSCC	NUPR1	proliferation↓	SCC-9 and HSC-2	—	—	[25]
OSCC	NUPR1	growth↓, invasion↓, EMT↓, and apoptosis↑	Tca8113 and SCC-9	tumor growth↓, EMT↓	BALB/c nude mice (4–6 weeks)	[35]
ccRCC	—	invasion↑ and migration↑	Caki1 and ACHN	—	—	[40]
OC	KLK4	proliferation↓, invasion↓, and migration↓	OVCAR-3 and H8910	—	—	[28]
OC	PLXNB2	proliferation↓, invasion↓, migration↓, and apoptosis↑	SKOV3 and CAOV3	tumor growth↓	BALB/c nude mice	[27]
TNBC	LIF	cell cycle↓, apoptosis↑, and autophagy↑	MDA-MB-231	tumor growth↓, metastasis ↓	female nude mice	[29]
	AKT1	proliferation↓ and migration↓	BT-549 and MDA-MD-231	tumorigenesis ↓, migration ↓, metastasis ↓	female BALB/c nude mice	[37]
	AKT3	—	—	tumor growth↓	female BALB/c nude mice	[37]
CCa	RING1	proliferation↓	SiHa and C-4 I	tumor growth↓	nude mice	[30]
SaOS	STAT3	invasion↓ and migration↓	U2OS and SW1353	—	—	[31]
SaOS	HDAC4	proliferation↓, invasion↓, and migration↓	HOS and U2OS	—	—	[32]
MM	NUPR1	proliferation↓, apoptosis↑, and autophagy↓	U266 and RPMI8226	—	—	[33]
CML	ABL1	proliferation↓ and apoptosis↑	K562	—	—	[34]

GBM glioblastoma multiforme, LGG low-grade glioma, PTC papillary thyroid carcinoma, TC thyroid gland carcinoma, NSCLC non-small cell lung cancer, GC gastric cancer, HCC hepatocellular carcinoma, CRC colorectal cancer, PDAC pancreatic ductal adenocarcinoma, CHOL human cholangiocarcinoma, OSCC oral squamous cell carcinoma, ccRCC clear cell renal cell carcinoma, OC ovarian cancer, TNBC triple-negative breast cancer, CCa cervical cancer, SaOS osteosarcoma, MM multiple myeloma, CML chronic myeloid leukemia, EMT epithelial-mesenchymal transition

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ISSN: 2050-7771

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