The Wnt/β-catenin signalling pathway in Haematological Neoplasms

Biomarker Research

Table 3 Wnt/β-catenin-related molecular mechanisms in multiple myeloma

Factor	Target	Disease	Effect
miR-744-5p/SOX12	β-catenin	MM	promote apoptosis and inhibit proliferation [102, 103]
miR-30-5P/BCL9	Wnt	MM	restrain the proliferation and migration of cancer cells [106]
miR-128-3p/PLAGL2	β-catenin	MM	restrain the proliferation and migration of cancer cells [108]
RRM2	GSK3β	MM	induce apoptosis [110]
PCDH10/AKT	GSK3β	MM	promote proliferation and restrain apoptosis [111]
Lycorine	β-catenin	MM	restrain MMSCs [112]
DHA	β-catenin	MM	induce autophagy [113]
resveratrol	nuclear translocation of β-catenin	MM	restrain the proliferation and migration of cancer cells [114]
CGK012	β-catenin	MM	restrain the proliferation of cancer cells [115]

ISSN: 2050-7771