Table 1 Wnt/β-catenin-related molecular mechanisms in leukaemia
From: The Wnt/β-catenin signalling pathway in Haematological Neoplasms
Factor | Target (location) | Disease | Effect |
|---|---|---|---|
P13K/AKT | GSK3β | ALL | decrease drug resistance of LSCs [58] |
LY294002/P13K/AKT | GSK3β | T-ALL | decrease the effects of P13K/AKT signalling [59] |
MYCN/DKK3 | β-catenin | B-ALL | promote the proliferation of cancer cells [68] |
FLT3 | β-catenin | AML | induce the expression of c-Myc [70] |
FLYWCH1 | β-catenin (nucleus) | AML | inhibit cell cycle progression at G0 [71] |
DIXDC1 | β-catenin (nucleus) | AML | promote the proliferation of cancer cells [72] |
CEBPA/PLIN2 | β-catenin | CML | promote the development of CML [74] |
RNA LOC101928834/FRAT2 | GSK3β | AML/MM | promote the proliferation of cancer cells [83] |