Table 2 Some ISGs that were demonstrated as tumor suppressors
From: Direct and indirect effects of IFN-α2b in malignancy treatment: not only an archer but also an arrow
Gene symbol | Antiviral mechanism | Cancer type | Anticancer action | Citation |
|---|---|---|---|---|
IFIT2 | Inhibiting viral protein synthesis and interfering with viral replication | Gallbladder carcinoma | Inhibition of cell proliferation and metastasis | |
Colon cancer | Inhibition of cell proliferation and induction of cell cycle arrest and apoptosis | |||
Gastric cancer | Inhibition of cell proliferation and migration and induction of cell cycle arrest | |||
MX1 | Acting as GTPase and blocking viral genome transcription | Prostate cancer | Induction of apoptosis and autophagy | |
SAMHD1 | Inducing the degradation of dNTPs and inhibiting the synthesis of viral DNA | Sézary syndrome | Inhibition of cell proliferation and induction of apoptosis | |
Chronic lymphocytic leukemia | Induction of cell cycle arrest and apoptosis | |||
Colon cancer | Inhibition of DNA replication | |||
APOBEC3 | Inducing viral genome mutations | Acute myeloid leukemia | Increasing genome fragility and enhancing the anticancer effects of other agents | |
Ovarian cancer | Associated with T cell infiltration | |||
EIF2AK2 | Phosphorylating eIF2α and blocking viral mRNA translation | Melanoma | Inhibition of cell proliferation and induction of apoptosis | |
Breast cancer | Inhibition of cell proliferation and enhancing the anticancer effects of other agents | |||
Cervical cancer | Induction of apoptosis | |||
OAS1 | Activating RNase L and interfering viral replication | Breast cancer | Inhibition of cell proliferation and metastasis and induction of cell cycle arrest and apoptosis |