Fig. 4

Inhibition of METTL1 reduces the tumorigenicity of NBL cells in vivo. A, B Tumor profiles of mice implanted with METTL1 knockdown and control NBL cells (N = 5). C, D Quantification of tumor weight (C) and size (D) at endpoints. E Growth curves of tumor volumes in the METTL1 knockdown and control groups. F Representative images of METTL1 and Ki67 IHC staining. G Quantitative analysis of IHC scores for METTL1 and Ki67. Data are presented as Mean ± SEM. P values were calculated by Mann-Whitney U test