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Fig. 1 | Biomarker Research

Fig. 1

From: METTL1 promotes neuroblastoma development through m7G tRNA modification and selective oncogenic gene translation

Fig. 1

METTL1 is elevated in advanced NBLs and is associated with poor prognosis in NBL patients in the GEO database (GSE62564). A The R2 genomics analysis and visualization platform showed a heatmap of correlations between METTL1 mRNA levels, COG risk, INSS stage, and MYCN status in NBL samples from the GEO database. B The GEO database showed the mRNA level of METTL1 in NBL samples at different stages (except stage4S, N = 53). C GEO database showed METTL1 mRNA levels in high-risk NBL samples and non-high-risk NBL samples. D Kaplan-Meier analysis of the event-free survival of patients grouped by METTL1 expression (N = 498). E, F Event-free survival based on METTL1 expression in the non-high risk cohort (E, N = 322) and high risk cohort (F, N = 176). Data are presented as Mean ± SEM. P values were calculated by two-tailed Student’s test for (B, C) and Log-rank test for (D-F)

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Biomarker Research

ISSN: 2050-7771

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