Fig. 1

T-cell regulatory biomarkers of immunotherapy for gastric cancer. a PD-1, CTLA4, LAG3, Tim3 and TIGIT act as inhibitory molecules, and OX40 acts as a costimulatory molecule. Activation of inhibitory molecules or loss of costimulatory molecules can lead to T-cell exhaustion. b The usage of anti-PD-1 inhibitors, etc., or OX40 agonists can activate T cells to kill tumor cells