Fig. 2
From: Advances of cancer-associated fibroblasts in liver cancer
The origin and the role of CAFs in liver cancer. Schematic illustration of potential cellular origins of CAFs, including epithelial cells, endothelial cells, tumor cells, HSCs, portal fibroblasts, and MSCs. The upper part of the picture shows the the influence exerted by CAFs in the TME, including chemoresistance, stemness induction, tumor immune, angiogenesis, and aggressiveness