Fig. 6

Differential expression (DE) analysis by DESeq2 between CD61+ and CD9, CD63 or CD81+ EV datasets on the healthy donor cohort. (A) Volcano plot showing DE genes between the two groups. Cut-offs were defined for adjusted p-values (0.05, Y axis) and log2 fold change (2, X axis). Upregulated and downregulated genes were depicted by green and red circles, respectively. (B) Supervised hierarchical clustering heatmap analysis based on the four DE genes discovered by DESeq2, samples and their respective group