Fig. 1

TRAF3IP2 is overexpressed in NONO-TFE3 tRCC and critical for malignant phenotypes. A The protein level of TRAF3IP2 was analyzed by immunohistochemistry in NONO-TFE3 tRCC and ccRCC. B, D Analysis of TRAF3IP2 in KIRC and KIRP tissues compared with normal tissues were performed using TCGA data. C, E Kaplan–Meier analysis revealed the disease-free survival (DFS) in KIRC patients based on the relative TRAF3IP2 expression. F Analysis of TRAF3IP2 in ccRCC tissues compared with normal tissues was performed using GEO data (GSE22316). G-I The protein and mRNA levels of TRAF3IP2 was analyzed by qRT-PCR and western blot assay in ccRCC cell line (786-O and ACHN), tRCC cell lines (UOK109 and UOK120) and normal renal cell lines (HK-2 and HEK 293 T). The data are presented as the mean ± SD, *P < 0.05, ***P < 0.001