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Fig. 2 | Biomarker Research

Fig. 2

From: Dynamic change of soluble interleukin-2 receptor distinguished molecular heterogeneity and microenvironment alterations in diffuse large B-cell lymphoma

Fig. 2

Lymphoma microenvironment of sIL-2R subtypes. a Gene Set Enrichment Analysis (GSEA) revealed oncogenic signaling pathway alterations in RES and RET subtypes compared with FINE subtype. b GSEA revealed immune-associated pathway alterations in RES and RET subtypes compared with FINE subtype. c Recruiting activity scores of immune cells between RES and FINE subtypes. Represented as mean ± SD. d Recruiting activity scores of immune cells between RET and FINE subtypes. Represented as mean ± SD. e Protein-protein interaction between IL-2R, multiple inhibitory receptors, and main proteins involved in JAK-STAT pathway. Green, black, pink and blue lines indicated interactions text mining, co-expression, experimentally-determined and from curated database, respectively. f The prevalence of lymphoma microenvironment (LME) classifications among sIL-2R subtypes. P value of specific LME was calculated between certain subtype and FINE subtype. * P < 0.05

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Biomarker Research

ISSN: 2050-7771

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