Small biomarkers with massive impacts: PI3K/AKT/mTOR signalling and microRNA crosstalk regulate nasopharyngeal carcinoma

Table 1 miRNAs regulating the PI3K/AKT signalling pathway in the pathogenesis of NPC

miRNA	Target	Molecular alteration	Function	Reference
miR-3188	mTOR	Downregulation	Inhibits proliferation and chemoresistance	[116]
miR-331-3p	elF4B	Downregulation	Inhibits survival and metastasis	[117]
miR-34a	AXL	Downregulation	Inhibits invasion and EMT	[118]
miR-122	TRIM29	Downregulation	Inhibits progression and metastasis	[119, 120]
miR-375	USP1	Downregulation	Inhibits migration and invasion	[121]
miR-206	IGF1	Downregulation	Promotes radiosensitization	[81]
miR-29a	VEGF	Downregulation	Inhibits cell proliferation	[122]
miR-16	FGF2	Downregulation	Inhibits cell proliferation	[123]
miR-144-3p	PTEN	Upregulation	Promotes cell proliferation and invasion	[124]
miR-155	PTEN	Upregulation	Promotes proliferation and inhibits apoptosis	[96]
miR-205-5p	PTEN	Upregulation	Promotes the EMT	[125]
miR-144	PTEN	Upregulation	Promotes cell proliferation and migration	[126]
EBV-miR-BART7-3p	PTEN	Upregulation	Enhances cell migration and invasion	[127]
EBV-miR-BART1	PTEN	Upregulation	Enhances cell migration and invasion	[127]
miR-192	RB1	Upregulation	Induces cell growth, invasion, and metastasis	[128]
miR-93	TGFβR2	Upregulation	Inhibits apoptosis	[129]

ISSN: 2050-7771