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Table 2 Univariate and multivariate logistic regression analyses of clinical and biological parameters for the prediction of DTX response after chemotherapy

From: circCYP24A1 promotes Docetaxel resistance in prostate Cancer by Upregulating ALDH1A3

Parameters

Univariable logistic regression

Multivariable logistic regression

OR

95% CI

P

OR

95% CI

P

Age (years)

0.993

0.931–1.059

0.830

   

PSA pre-treatment (ng/ml)

0.999

0.994–1.004

0.596

   

Prostate volume (ml)

0.965

0.890–1.047

0.395

   

PSA post-treatment (ng/ml)

0.072

0.007–0.719

0.025

0.033

0.002–0.609

0.022

Tumor max diameter on MRI

0.792

0.504–1.244

0.311

   

PI-RADS

 4 vs. 3

0.333

0.043–2.564

0.291

   

 5 vs. 3

0.538

0.082–3.526

0.519

   

Clinical T stage

 T3a vs. T4

1.944

0.383–9.883

0.423

   

 T3b vs. T4

0.942

0.193–4.595

0.941

   

ISUP grade at biopsy

 2 vs 1

0.089

0.009–0.839

0.035

0.137

0.007–2.824

0.198

 3 vs 1

0.667

0.076–5.878

0.715

0.538

0.027–10.591

0.684

 4 vs 1

0.232

0.038–1.401

0.111

0.331

0.026–4.205

0.394

 5 vs 1

0.400

0.057–2.800

0.356

0.423

0.026–6.750

0.542

circCYP24A1 expression

 Low vs High

0.135

0.045–0.407

< 0.001

0.165

0.038–0.723

0.017

miR-1301-3p expression

 Low vs High

3.000

1.117–8.058

0.029

1.096

0.252–4.766

0.903

ALDH1A3 expression

 Low vs High

0.347

0.130–0.926

0.035

0.426

0.099–1.832

0.251

  1. Significant P values were presented in bold text
  2. MRI magnetic resonance imaging, PSA prostate specific antigen, ISUP International Society of Urological Pathology, PI-RADS Prostate Imaging Reporting and Date System, OR Odds ratio, CI confidence intervals