Fig. 5

CircCYP24A1 sponges miR-1301-3p to regulate DTX sensitivity in PCa cells. A The expression of miR-1301-3p in DU145-DR cells transfected with miR-1301-3p mimics. B The expression of miR-1301-3p in DU145-DR cells transfected with shcircCYP24A1 and miR-1301-3p inhibitor. C CCK-8 data for the IC50 of DU145-DR cells treated with 20 nM DTX after transfection with miR-1301-3p inhibitor combined with or without sh-circCYP24A1. D-E The indicated cells were treated with 20 nM DTX and subjected to detect apoptotic rate (D) or cell cycle (E) by flow cytometry. F Statistical analysis of the apoptotic rate. G Statistical analysis of the cell cycle. All data are presented as the means ± SD of three independent experiments. n = 3, *P < 0.05, **P < 0.01, ***P < 0.001