Fig. 3

Knocking down circCYP24A1 suppressed the DTX chemoresistance of PCa in vivo. A Schematic diagram illustrates the xenograft mouse model treated by indicated concentration of DTX. B, C Images of the BALB/c nude mice (B) and the tumor xenografts (C) at the endpoint. D Tumor growth curves of tumor sizes are shown. Tumor volumes were measured every 3 days since the first DTX treatment. E Tumor volumes measured at the experimental endpoint. F Representative images of H&E and IHC (Cleaved caspase 3 and Ki67) staining of the xenograft tumors. G TUNEL staining of the xenograft tumors. All data are presented as the means ± SD of three independent experiments. n = 6, ***P < 0.001