Table 2 circRNA influence chemoresistance of hematological malignancies
Circ based ID / Common Name | Hematological malignancies | Expression pattern | Target miRNA/Target gene | Drug resistance | Ref. |
|---|---|---|---|---|---|
circ-0000190 | CML | ↑ | miR-34a-5p/ULK1 | Increasing chemoresistance of imatinib | |
CircANXA2 | AML | ↑ | miR-23a-5p/ miR-503-3p | Increasing chemoresistance of cytarabine and daunorubicin | [74] |
CircPAN3 | AML | ↑ | miR-153-5p/miR-183-5p-XIAP axis/AMPK/mTOR signaling | Inducing chemoresistance of ADM | [26] |
circ-0003489 | MM | ↑ | miR-874-3p/HDAC1 axis | Inducing chemoresistance of BTZ | [75] |
CircNPM1 | AML | ↑ | miR-345-5p/FZD5 pathway | Increasing Adriamycin resistance | [85] |
Circ-ITCH | MM | ↓ | miR-615-3p/PRKCD axis | Increasing bortezomib sensitivity | [86] |
circ-0080145 | CML | ↑ | miR-326/PPFIA1 axis | Increasesing imatinib resistance | [87] |